Biochem/physiol Actions

Target IC₅₀: 1.5 nM against I338G mutant v-Src; 1.0 µM against wild-type v-Src; 600 nM against wild-type Fyn

Reversible: yes

Product competes with ATP.

Cell permeable: yes

Primary TargetI338G mutant v-Src

General description

A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1.0 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). Also available in InSolution™ format (Cat. No. 529605).

A potent, reversible, ATP-competitive, cell-permeable and selective inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). Also available in InSolution™ format (Cat. No. 529605).

Legal Information

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bishop, A.C., et al. 2000. Nature407, 395.Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.

Warning

Toxicity: Standard Handling (A)